elment info. • Inhibits p53, Treatment of Arsenic Poisoning • Chelation therapy removes heavy metals • Dimercaprol • First antidote • Intramuscular Injection (painful) • Narrow therapeutic window • DMSA • Currently used • Fewer side effects • Can be administered orally Dimercaprol Dimercaptosuccinic acid (DMSA) Dimercaptosuccinic acid (DMSA), Summary • Symptoms include headache, drowsiness, diarrhea, vomiting, bloody urine, convulsions, changes in fingernail pigmentation • Enters body via inhalation and/or ingestion and mainly distributes to liver • Inorganic arsenate is metabolized in liver by methylation to MMA and DMA. peter worcester a period. atomic number is 33 atomic mass is 75 family: 15 nitrogen. loveland tech4good luke whitaker / may 27, 2014. arsenic detection techniques. Arsenic contamination of groundwater is a form of groundwater pollution which is often due to naturally occurring high concentrations of arsenic in deeper levels of groundwater. What structures, physical and chemical properties, Poisoning - . See our Privacy Policy and User Agreement for details. Acute Poisoning: Symptoms of acute intoxication usually occur within 30 minutes of ingestion but may be delayed if arsenic is taken with the food. Lead (Pb) has been used by humans for at least 7000 years, because it is widespread, easy to extract, and easy to work with. Long-term Natural Arsenic Levels Crystalline Rock Soil Ground Water Surface Water Avg. arsenic compliance in perspective water, Arsenic - . Retrieved from Lecture Notes Online Website: http://mstc.csmu.edu.tw/ezcatfiles/mstc/img/img/466/961008-BarryPhilipRosen.pdf Sears, M. E. (2013). Arsenic Poisoning - Free download as Powerpoint Presentation (.ppt / .pptx), PDF File (.pdf), Text File (.txt) or view presentation slides online. Arsenic toxicity and potential mechanisms of action. 33. as arsenic 75. arsenic. Contamination is caused by arsenic from natural geological sources leaching into aquifers, contaminating drinking water and may also occur from mining and other industrial processes. Arsenic poisoning acts on different metabolic pathways of glucose metabolism. Metabolism • Main organ for arsenic metabolism is the liver, Metabolism continued Step 1 • Inorganic pentavalent arsenate is reduced to trivalent arsenite in the blood stream before entering the cells • Can occur non-enzymatically in the presence of a thiol such as glutathione (GSH), Metabolism continued Step 2 • Methylation to monomethylarsonic acid (MMA) and to dimethyl- arsinic acid (DMA) is enzymatic, requiring S- adenosylmethionine (SAM) and a methyltransferase • MMA and DMA are excreted in the urine (thousandfold less-potent as mutagenic agents than inorganic arsenic) • Methylation has long been considered the main route of detoxification, but there is growing literature supporting other methods such as transport and antioxidant defenses, Mechanism of Action of (As3+) • Reacts with thiol-containing molecules (R-SH) • Arsenite inhibits GSH Reductase by interacting with critical thiol groups • Blocks production of GSH (glutathione, important antioxidant) causing increased free radicals and oxidative damage • Increased production of ROS such as superoxide radical, singlet Oxygen, hydroxyl radicals, hydrogen peroxide, Mechanism of Action of (As3+) • Inhibits lipoicacid (a dithiol) which is an important cofactor for Pyruvate Dehydroxygenase (PDH) • As [Acetyl CoA] decreases  Citric Acid Cycle activity decrease, causing: • Decreased ATP production • Decreased Gluconeogenesis (synthesis of glucose from carbohydrates, fatty acids, proteins, etc) Function of PyruvateDehydroxygenase: Oxidize Pyruvate to Acetyl CoA before Citric Acid Cycle Arsenic binds to Lipoid Acid-PDH to form 6-member ring Lipoic Acid-PDH, Arsenate resembles Inorganic Phosphate Competitively inhibits phosphate for active site in G3P-Dehydroxygenase Replaces phosphate in many biochemical reactions in cellular respiration ATP ADP-arsenate (arsenolytic mechanism – uncouples ATP formation) Glucose-6-Phosphate  Glucose-6-Arsenate Glyceraldehyde-3-Phosphate  Glyceraldehyde-3-Arsenate Mechanism of Action of (As5+) Inorganic Phosphate is chemically similar to Inorganic Arsenate, Inhibition of Glyceraldehyde-3-Phosphate dehydrogenase, Arsenic is a Carcinogen • Associated with oxidative stress, cell arrest in the G2/M phase, chromosomal abnormalities, and DNA aneuploidy. Mechanism of arsenic poisoning Adrian Bumstead, Xiao Qi Li, Jessica So, Jin (Donna) Yang PHM142 Fall 2015 Instructor: Dr. Jeffrey Henderson Overall - try to keep the text to a minimum (the presentation guideline for the cardio Arsenic Trade Show Treatment Options Overview The main considerations when selecting a treatment technology include: Water quality characteristics (including pH levels and initial concentrations of iron, As(III), and As Arsenic is a natural component of the earth’s crust and is widely distributed throughout the environment in the air, water and land. © 2020 SlideServe | Powered By DigitalOfficePro, - - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -. Dr Kaleem Khan Assistant Professor JNMCH 2. Furthermore, it was observed that new cases of human poisoning … | PowerPoint PPT PHM142 Fall 2013 Instructor: Dr. Jeffrey Henderson. The patient, a chemist by profession, prepared this amount of arsenic trioxide in his factory laboratory using a commercial solution of arsenic trichloride (AsCl3) as a base. His blood picture and abdomen radiography were as in the images. +3. As 33 74.99. This a special article from Telugudoctors.co.in; Hope you find it useful and informative. APIdays Paris 2019 - Innovation @ scale, APIs as Digital Factories' New Machi... No public clipboards found for this slide. -3. Stools were initially Rice water type but later became bloody
On examination he had some nail changes, sensory loss and dermatitis like picture. SOS-Arsenic: Private Iniciative against Poisoning of Ground Water in Bangladesh The arsenic hazard in Bangladesh villagers now appeared as a ‘real disaster', affecting thousands physically, physiologically, mentally and economically; it is intensifying malnutrition, … Wayne State University School of Medicine [PDF Document]. Arsenic, element 33, has a long and nefarious history; its very name has become synonymous with poison. by, jeremy rubert. Arsenic Detection Techniques - . (2002). Retrieved from http://library.concordia.ca/help/howto/apa.php#online Hughes,M, F. Beck, B,D et al. Arsenic - . See our User Agreement and Privacy Policy. Arsenic - Laura stanton. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. Diagnosis of arsenic poisoning is made by determining inorganic and organic levels of arsenic in the blood and urine. arsenic - . substance which when introduced into body in relatively small amounts causes in structural damage, Arsenic Rule - . poisoning. 1. Arsenic poisoning( acute, subacute and chronic) 1. 2 ppm 1-40 ppm 0.01 – 800 ppb As high as 40,000 in hot springs 2.38 – 65 ppb Some Arsenic Uses/Anthropogenic Sources • Smelting of metals A brief presentation on Arsenic poisoning encompassing 40 slides - also included is a quiz on toxicology at the end. Arsenic: toxicity, oxidative stress and human disease. China lead poisoning(2009) Zamfara lead poisoning(Mar-June 2010): About 163 deaths due to illegal extraction of ore by villagers in Anka & Bukuyyum LGA’s. seafood –, Poisoning - . Get powerful tools for managing your contents. The Scientific World Journal, 2013, 13 Pages. everyone reacts differently. Print. EvironmnetalChemistry.com. Arsenic. small systems implementation strategy & exemptions. Toronto: Oxford UP, 2009. (2011). Arsenic poisoning 1. If you continue browsing the site, you agree to the use of cookies on this website. PHM142H1-F October 9, 2013. It is a high-profile problem due to the use of deep tube wells for water supply in the Ganges Delta , causing serious arsenic poisoning to large numbers of people. +5. Distribution • The largest quantity of arsenic is found in the liver. as atomic number: 33 relative mass: 74.92 metalloid grey or yellow or black, Poisoning - . 6 th period by: katelyn keller brianna leslie tiffany goulart. New technologies require behavioral change on the part of the user, thus Request PDF | On Jan 1, 2000, D. N. Guha Mazumder published Chapter 4 : Diagnosis and treatment of chronic arsenic poisoning | Find, read and cite all the research you need on ResearchGate jonathan kernaghan. Clipping is a handy way to collect important slides you want to go back to later. group 15, metalloid (category/group) germanium, gallium, it sublimates, Arsenic - . Arsenic - . morgan dunn stevie turner. Arsenic poisoning is a medical condition that occurs due to elevated levels of arsenic in the body. Symptoms of arsenic poisoning, or arsenicosis, can include skin lesions, swollen limbs and loss of feeling in the hands and legs. Guide to Nutritional Supplements. o vervie w. efficiency chemical structures uses problems, Poisoning - . Homeostasis and Toxicology of Non-Essential Metals. sources . ARSENIC POISONING A. 33 2,8,18,5 as arsenic 74.92160. electron diagram. He also used to complain of tingling and numbness over his hands and foot.
He gives history of having consumed water from his work place for the past 3 days as he forgot to carry his own bottle and has been suffering from severe gastroenteritis ever since. Arsenic toxicity is a global health problem affecting many millions of people. arsenic. Arsenic as a Global Pollutant - Arsenic as a Global Pollutant Tiffany Berg March 26th, 2011 Health effects of arsenic poisoning Keratosis Internal tumors Cancers of the skin, liver, bladder, and lungs. p.861-864. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Arsenic has been used since 3000 BC. this element's name was derived from " arsenikon. Talanta, 58, 201-235. http://dx.doi.org/10.1016/S0039-9140(02)00268-0 Miller, W., Schipper, H., Lee, S., et al. Toxicology Letters 133:1-16 Jomova, K., Jenisova, Z., Feszterova, M., Baros, S., Liska, J., Hudecova, D., Rhodes, C.J., Valko, M. (2010). Treatment of arsenic poisoning in acute toxic poisonings needs to begin quickly; treatment involves removal of arsenic by dialysis , chelating agents, replacement of red blood cells , and if ingested, bowel cleansing. References Caballero, B.(2009). Chelation: Harnessing and Enhancing Heavy Metal Detoxification- a review. poisoning. – A free PowerPoint PPT presentation (displayed as a Flash Arsenic is present as a contaminant in many traditional remedies. • Carcinogenic due to oxidative stress, inhibition of p53, genotoxicity, altered DNA repair mechanisms and tumor promotion • “Arsenite” - Trivalent (As3+): Reacts with reacts with thiols and sulfhydryl groups • Inhibits GSH Reductaseblocks of GSH production Oxidative stress and production of free radicals • Inhibits Pyruvate Dehydroxygenase decreased activity in Citric Acid Cycle decreased ATP production and Gluconeogenesis • “Arsenate” - Pentavalent (As5+): replaces phosphate groups because of similar molecular structure).